Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0003000 | Exon-Exon | chr21:38459547-38524329 | chr21:37087247-37152029 | 2424 nt | 0.3767 |
| hsa_TTC3_0003100 | Exon-Intron | chr21:38459547-38527327 | chr21:37087247-37155026 | 250 nt | 0.4000 |
| hsa_TTC3_0003200 | Exon-Exon | chr21:38459547-38529208 | chr21:37087247-37156906 | 250 nt | 0.3440 |
| hsa_TTC3_0003300 | Exon-Exon | chr21:38459547-38534365 | chr21:37087247-37162063 | 250 nt | 0.3360 |
| hsa_TTC3_0004900 | Exon-Exon | chr21:38459547-38545046 | chr21:37087247-37172744 | 161 nt | 0.4410 |
| hsa_TTC3_0003400 | Exon-Exon | chr21:38459547-38555215 | chr21:37087247-37182913 | 250 nt | 0.2960 |
| hsa_TTC3_0003500 | Exon-Exon | chr21:38459547-38558075 | chr21:37087247-37185774 | 250 nt | 0.3240 |
| hsa_TTC3_0003600 | Exon-Exon | chr21:38459547-38560896 | chr21:37087247-37188595 | 250 nt | 0.3720 |
| hsa_TTC3_0003700 | Exon-Exon | chr21:38459547-38573871 | chr21:37087247-37201570 | 250 nt | 0.4240 |
| hsa_TTC3_0005100 | Exon-Exon | chr21:38459576-38480746 | chr21:37087276-37108446 | 882 nt | 0.3628 |
Showing 91 to 100 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].