Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0005200 | Exon-Exon | chr21:38459613-38462586 | chr21:37087313-37090286 | 425 nt | 0.3741 |
| hsa_TTC3_0005300 | Intron-Intron | chr21:38459811-38459965 | chr21:37087511-37087665 | 155 nt | 0.4387 |
| hsa_TTC3_0005500 | Exon-Exon | chr21:38460133-38461186 | chr21:37087833-37088886 | 282 nt | 0.3723 |
| hsa_TTC3_0005600 | Exon-Exon | chr21:38460133-38467744 | chr21:37087833-37095444 | 638 nt | 0.3354 |
| hsa_TTC3_0005700 | Exon-Exon | chr21:38460133-38468943 | chr21:37087833-37096643 | 701 nt | 0.3409 |
| hsa_TTC3_0005800 | Exon-Exon | chr21:38460133-38498443 | chr21:37087833-37126143 | 1153 nt | 0.3651 |
| hsa_TTC3_0005900 | Intron-Exon-Intron | chr21:38460436-38461186 | chr21:37088136-37088886 | 299 nt | 0.3378 |
| hsa_TTC3_0006200 | Exon-Exon | chr21:38460496-38462586 | chr21:37088196-37090286 | 293 nt | 0.3584 |
| hsa_TTC3_0006300 | Exon-Exon | chr21:38460496-38480746 | chr21:37088196-37108446 | 713 nt | 0.3492 |
| hsa_TTC3_0006400 | Exon-Exon | chr21:38460496-38519903 | chr21:37088196-37147603 | 1829 nt | 0.3778 |
Showing 101 to 110 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].