Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0006500 | Exon-Exon | chr21:38460524-38468943 | chr21:37088224-37096643 | 630 nt | 0.3397 |
| hsa_TTC3_0006600 | Exon-Exon | chr21:38460547-38468943 | chr21:37088247-37096643 | 63 nt | 0.3968 |
| hsa_TTC3_0006700 | Exon-Intron | chr21:38460608-38469206 | chr21:37088308-37096906 | 809 nt | 0.3375 |
| hsa_TTC3_0007000 | Intron-Intron | chr21:38461286-38461554 | chr21:37088986-37089254 | 269 nt | 0.4126 |
| hsa_chr21_0073500 | Intergenic-Intergenic | chr21:38461890-38462114 | chr21:37089590-37089814 | 225 nt | 0.5511 |
| hsa_TTC3_0007100 | Exon-Exon | chr21:38462533-38466390 | chr21:37090233-37094090 | 102 nt | 0.3137 |
| hsa_TTC3_0007300 | Exon-Exon | chr21:38463593-38466390 | chr21:37091293-37094090 | 207 nt | 0.3140 |
| hsa_TTC3_0007400 | Exon-Exon | chr21:38463593-38480746 | chr21:37091293-37108446 | 420 nt | 0.3429 |
| hsa_TTC3_0007500 | Exon-Exon | chr21:38463593-38498443 | chr21:37091293-37126143 | 64 nt | 0.4688 |
| hsa_TTC3_0008000 | Exon-Exon | chr21:38466305-38498443 | chr21:37094005-37126143 | 64 nt | 0.4688 |
Showing 111 to 120 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].