Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0008100 | Exon-Exon | chr21:38466305-38501363 | chr21:37094005-37129063 | 92 nt | 0.3261 |
| hsa_TTC3_0007700 | Exon-Exon | chr21:38466305-38505066 | chr21:37094005-37132766 | 842 nt | 0.3777 |
| hsa_TTC3_0007800 | Exon-Exon | chr21:38466305-38519903 | chr21:37094005-37147603 | 1415 nt | 0.3873 |
| hsa_TTC3_0007900 | Exon-Exon | chr21:38466305-38520947 | chr21:37094005-37148647 | 1517 nt | 0.3830 |
| hsa_TTC3_0007600 | Exon-Exon | chr21:38466305-38532047 | chr21:37094005-37159745 | 2438 nt | 0.3802 |
| hsa_TTC3_0008500 | Exon-Exon | chr21:38467650-38501363 | chr21:37095350-37129063 | 671 nt | 0.3830 |
| hsa_TTC3_0008800 | Exon-Exon | chr21:38467650-38505066 | chr21:37095350-37132766 | 180 nt | 0.3500 |
| hsa_TTC3_0008600 | Exon-Exon | chr21:38467650-38519903 | chr21:37095350-37147603 | 1329 nt | 0.3920 |
| hsa_TTC3_0008700 | Exon-Exon | chr21:38467650-38520947 | chr21:37095350-37148647 | 1431 nt | 0.3871 |
| hsa_TTC3_0008400 | Exon-Exon | chr21:38467650-38525577 | chr21:37095350-37153277 | 2053 nt | 0.3799 |
Showing 121 to 130 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].