Basic Information

Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3 RNF105 DCRR1 TPRDIII TPRD RING-Type E3 Ubiquitin Transferase TTC3 Tetratricopeptide Repeat Protein 3 E3 Ubiquitin-Protein Ligase TTC3 RING Finger Protein 105 TPR Repeat Protein 3 TPR Repeat Protein D TPRDII TPRDI Protein DCRR1 EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408 UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
UCSC Genome Browser Search in Marker Scope
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_TTC3_0008900 Intron-Intron chr21:38467745-38468841 chr21:37095445-37096541 1097 nt 0.3883
hsa_TTC3_0009000 Exon-Exon chr21:38468881-38495328 chr21:37096581-37123028 327 nt 0.3976
hsa_TTC3_0009100 Exon-Exon chr21:38468881-38511014 chr21:37096581-37138714 87 nt 0.4483
hsa_chr21_0073600 Intergenic-Intergenic chr21:38468883-38480735 chr21:37096583-37108435 105 nt 0.4095
hsa_TTC3_0009200 Intron-Intron chr21:38468944-38469206 chr21:37096644-37096906 263 nt 0.3384
hsa_TTC3_0009500 Intron-Exon chr21:38469021-38470460 chr21:37096721-37098160 1440 nt 0.3396
hsa_TTC3_0009600 Intron-Exon chr21:38469021-38470512 chr21:37096721-37098212 186 nt 0.3495
hsa_TTC3_0009400 Intron-Intron chr21:38469021-38472048 chr21:37096721-37099748 250 nt 0.2920
hsa_TTC3_0009700 Intron-Intron chr21:38469915-38470111 chr21:37097615-37097811 197 nt 0.3401
hsa_chr21_0073700 Intergenic-Intergenic chr21:38470412-38470715 chr21:37098112-37098415 304 nt 0.4342
Showing 131 to 140 of 299 entries
Forensic Context

A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].