Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0013500 | Exon-Exon | chr21:38480692-38522470 | chr21:37108392-37150170 | 61 nt | 0.4426 |
| hsa_TTC3_0012700 | Exon-Exon | chr21:38480692-38523184 | chr21:37108392-37150884 | 1431 nt | 0.3899 |
| hsa_TTC3_0012800 | Exon-Intron | chr21:38480692-38524386 | chr21:37108392-37152086 | 1625 nt | 0.3822 |
| hsa_TTC3_0012900 | Exon-Exon | chr21:38480692-38525486 | chr21:37108392-37153186 | 1804 nt | 0.3830 |
| hsa_TTC3_0013600 | Exon-Intron | chr21:38480692-38526912 | chr21:37108392-37154612 | 77 nt | 0.4935 |
| hsa_TTC3_0011600 | Exon-Intron | chr21:38480692-38527327 | chr21:37108392-37155026 | 250 nt | 0.3840 |
| hsa_TTC3_0011700 | Exon-Exon | chr21:38480692-38529208 | chr21:37108392-37156906 | 2147 nt | 0.3833 |
| hsa_TTC3_0013700 | Exon-Exon | chr21:38480692-38533160 | chr21:37108392-37160858 | 63 nt | 0.3333 |
| hsa_TTC3_0011800 | Exon-Exon | chr21:38480692-38538917 | chr21:37108392-37166615 | 250 nt | 0.3400 |
| hsa_TTC3_0013800 | Exon-Exon | chr21:38480692-38539922 | chr21:37108392-37167620 | 61 nt | 0.4590 |
Showing 151 to 160 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].