Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0013900 | Exon-Exon | chr21:38480692-38545046 | chr21:37108392-37172744 | 156 nt | 0.3910 |
| hsa_TTC3_0011900 | Exon-Exon | chr21:38480692-38555215 | chr21:37108392-37182913 | 250 nt | 0.2800 |
| hsa_TTC3_0014000 | Exon-Exon | chr21:38480692-38558075 | chr21:37108392-37185774 | 124 nt | 0.4113 |
| hsa_TTC3_0014100 | Exon-Exon | chr21:38480692-38560896 | chr21:37108392-37188595 | 55 nt | 0.4545 |
| hsa_TTC3_0012000 | Exon-Exon | chr21:38480692-38563725 | chr21:37108392-37191424 | 250 nt | 0.3240 |
| hsa_TTC3_0014200 | Exon-Exon | chr21:38480692-38564514 | chr21:37108392-37192213 | 55 nt | 0.4545 |
| hsa_TTC3_0012100 | Exon-Exon | chr21:38480692-38569997 | chr21:37108392-37197696 | 250 nt | 0.3160 |
| hsa_TTC3_0012200 | Exon-Exon | chr21:38480692-38570317 | chr21:37108392-37198016 | 250 nt | 0.4160 |
| hsa_TTC3_0012300 | Exon-Exon | chr21:38480692-38570326 | chr21:37108392-37198025 | 250 nt | 0.4080 |
| hsa_TTC3_0012400 | Exon-Exon | chr21:38480692-38572625 | chr21:37108392-37200324 | 250 nt | 0.3600 |
Showing 161 to 170 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].