Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0012500 | Exon-Exon | chr21:38480692-38574839 | chr21:37108392-37202538 | 250 nt | 0.3840 |
| hsa_TTC3_0014300 | Intron-Intron | chr21:38491174-38491358 | chr21:37118874-37119058 | 185 nt | 0.3243 |
| hsa_TTC3_0014400 | Intron-Exon-Intron | chr21:38493146-38507814 | chr21:37120846-37135514 | 1175 nt | 0.3983 |
| hsa_TTC3_0014900 | Exon-Exon | chr21:38494117-38495328 | chr21:37121817-37123028 | 209 nt | 0.3828 |
| hsa_TTC3_0015000 | Exon-Exon | chr21:38494117-38498443 | chr21:37121817-37126143 | 397 nt | 0.3955 |
| hsa_TTC3_0015600 | Exon-Exon | chr21:38494117-38501363 | chr21:37121817-37129063 | 61 nt | 0.3443 |
| hsa_TTC3_0015100 | Exon-Exon | chr21:38494117-38505066 | chr21:37121817-37132766 | 543 nt | 0.3904 |
| hsa_TTC3_0015200 | Exon-Exon | chr21:38494117-38511014 | chr21:37121817-37138714 | 759 nt | 0.4005 |
| hsa_TTC3_0015300 | Exon-Exon | chr21:38494117-38520947 | chr21:37121817-37148647 | 1218 nt | 0.3900 |
| hsa_TTC3_0015400 | Exon-Exon | chr21:38494117-38522470 | chr21:37121817-37150170 | 1311 nt | 0.3890 |
Showing 171 to 180 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].