Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0015500 | Exon-Exon | chr21:38494117-38525577 | chr21:37121817-37153277 | 1840 nt | 0.3810 |
| hsa_TTC3_0014700 | Exon-Exon | chr21:38494117-38529208 | chr21:37121817-37156906 | 2092 nt | 0.3815 |
| hsa_TTC3_0014800 | Exon-Exon | chr21:38494117-38545046 | chr21:37121817-37172744 | 250 nt | 0.3200 |
| hsa_TTC3_0015700 | Exon-Exon | chr21:38495283-38505066 | chr21:37122983-37132766 | 380 nt | 0.3895 |
| hsa_TTC3_0016000 | Exon-Exon | chr21:38495283-38507814 | chr21:37122983-37135514 | 135 nt | 0.4148 |
| hsa_TTC3_0015800 | Exon-Exon | chr21:38495283-38511014 | chr21:37122983-37138714 | 596 nt | 0.4027 |
| hsa_TTC3_0015900 | Exon-Exon | chr21:38495283-38512973 | chr21:37122983-37140673 | 709 nt | 0.4006 |
| hsa_TTC3_0016400 | Exon-Exon | chr21:38496919-38501363 | chr21:37124619-37129063 | 249 nt | 0.3936 |
| hsa_TTC3_0016700 | Exon-Exon | chr21:38496919-38512973 | chr21:37124619-37140673 | 124 nt | 0.3790 |
| hsa_TTC3_0016500 | Exon-Exon | chr21:38496919-38516945 | chr21:37124619-37144645 | 784 nt | 0.4005 |
Showing 181 to 190 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].