Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0016600 | Exon-Exon | chr21:38496919-38525577 | chr21:37124619-37153277 | 1631 nt | 0.3807 |
| hsa_TTC3_0016800 | Exon-Exon | chr21:38496997-38501363 | chr21:37124697-37129063 | 171 nt | 0.3918 |
| hsa_TTC3_0016900 | Exon-Exon | chr21:38498380-38505066 | chr21:37126080-37132766 | 210 nt | 0.4048 |
| hsa_TTC3_0017000 | Exon-Exon | chr21:38498380-38507814 | chr21:37126080-37135514 | 345 nt | 0.4087 |
| hsa_TTC3_0017200 | Exon-Exon | chr21:38501303-38512973 | chr21:37129003-37140673 | 475 nt | 0.4021 |
| hsa_TTC3_0017700 | Exon-Exon | chr21:38504982-38516945 | chr21:37132682-37144645 | 85 nt | 0.4000 |
| hsa_TTC3_0017600 | Exon-Exon | chr21:38504982-38522470 | chr21:37132682-37150170 | 853 nt | 0.3892 |
| hsa_TTC3_0017800 | Exon-Exon | chr21:38504982-38524329 | chr21:37132682-37152029 | 220 nt | 0.4091 |
| hsa_TTC3_0017900 | Exon-Exon | chr21:38504982-38525577 | chr21:37132682-37153277 | 85 nt | 0.4000 |
| hsa_TTC3_0017500 | Exon-Exon | chr21:38504982-38545046 | chr21:37132682-37172744 | 250 nt | 0.3000 |
Showing 191 to 200 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].