Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0018000 | Exon-Exon | chr21:38505037-38512973 | chr21:37132737-37140673 | 359 nt | 0.4150 |
| hsa_TTC3_0018100 | Exon-Exon | chr21:38507680-38516945 | chr21:37135380-37144645 | 450 nt | 0.4044 |
| hsa_TTC3_0018300 | Exon-Exon | chr21:38507680-38519903 | chr21:37135380-37147603 | 135 nt | 0.4148 |
| hsa_TTC3_0018400 | Exon-Exon | chr21:38507680-38525577 | chr21:37135380-37153277 | 135 nt | 0.4148 |
| hsa_TTC3_0018200 | Exon-Exon | chr21:38507680-38536517 | chr21:37135380-37164215 | 1892 nt | 0.3827 |
| hsa_TTC3_0018500 | Exon-Exon | chr21:38510934-38512973 | chr21:37138634-37140673 | 194 nt | 0.4124 |
| hsa_TTC3_0018600 | Intron-Exon-Intron | chr21:38510934-38513592 | chr21:37138634-37141292 | 813 nt | 0.3333 |
| hsa_TTC3_0018800 | Exon-Exon | chr21:38510934-38516945 | chr21:37138634-37144645 | 81 nt | 0.4444 |
| hsa_TTC3_0018900 | Exon-Exon | chr21:38510934-38519903 | chr21:37138634-37147603 | 81 nt | 0.4444 |
| hsa_TTC3_0019000 | Exon-Exon | chr21:38510934-38522470 | chr21:37138634-37150170 | 81 nt | 0.4444 |
Showing 201 to 210 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].