Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0018700 | Exon-Exon | chr21:38510934-38525577 | chr21:37138634-37153277 | 1162 nt | 0.3726 |
| hsa_TTC3_0019100 | Exon-Exon | chr21:38512861-38520947 | chr21:37140561-37148647 | 459 nt | 0.3725 |
| hsa_TTC3_0019200 | Exon-Exon | chr21:38512861-38522470 | chr21:37140561-37150170 | 552 nt | 0.3732 |
| hsa_TTC3_0019300 | Exon-Exon | chr21:38512861-38523184 | chr21:37140561-37150884 | 617 nt | 0.3712 |
| hsa_TTC3_0019400 | Exon-Exon | chr21:38512861-38524329 | chr21:37140561-37152029 | 754 nt | 0.3660 |
| hsa_TTC3_0019500 | Exon-Exon | chr21:38512861-38538917 | chr21:37140561-37166615 | 119 nt | 0.3866 |
| hsa_TTC3_0019600 | Intron-Exon-Intron | chr21:38516414-38517226 | chr21:37144114-37144926 | 813 nt | 0.3739 |
| hsa_TTC3_0019700 | Exon-Exon | chr21:38516825-38519903 | chr21:37144525-37147603 | 244 nt | 0.3852 |
| hsa_TTC3_0019800 | Exon-Exon | chr21:38516825-38520947 | chr21:37144525-37148647 | 346 nt | 0.3671 |
| hsa_TTC3_0020100 | Exon-Exon | chr21:38516825-38524329 | chr21:37144525-37152029 | 137 nt | 0.3431 |
Showing 211 to 220 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].