Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0021100 | Intron-Intron | chr21:38519904-38520782 | chr21:37147604-37148482 | 879 nt | 0.4300 |
| hsa_TTC3_0021200 | Exon-Exon | chr21:38520846-38525577 | chr21:37148546-37153277 | 724 nt | 0.3577 |
| hsa_TTC3_0021700 | Exon-Exon | chr21:38524193-38525577 | chr21:37151893-37153277 | 464 nt | 0.3621 |
| hsa_TTC3_0021900 | Exon-Exon | chr21:38525251-38525577 | chr21:37152951-37153277 | 327 nt | 0.3700 |
| hsa_TTC3_0021800 | Exon-Exon | chr21:38525251-38545046 | chr21:37152951-37172744 | 2204 nt | 0.4070 |
| hsa_chr21_0074200 | Intergenic-Intergenic | chr21:38525411-38526900 | chr21:37153111-37154600 | 1490 nt | 0.4148 |
| hsa_TTC3_0022000 | Exon-Exon | chr21:38525423-38536517 | chr21:37153123-37164215 | 155 nt | 0.3613 |
| hsa_chr21_0074300 | Intergenic-Intergenic | chr21:38525886-38526162 | chr21:37153586-37153862 | 277 nt | 0.3682 |
| hsa_chr21_0074400 | Intergenic-Intergenic | chr21:38526582-38527994 | chr21:37154282-37155693 | 1412 nt | 0.4278 |
| hsa_TTC3_0022100 | Intron-Exon-Intron | chr21:38526836-38536517 | chr21:37154536-37164215 | 2770 nt | 0.4094 |
Showing 231 to 240 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].