Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0022500 | Exon-Exon | chr21:38528957-38529208 | chr21:37156655-37156906 | 252 nt | 0.3849 |
| hsa_TTC3_0022600 | Exon-Exon | chr21:38528957-38533160 | chr21:37156655-37160858 | 410 nt | 0.3829 |
| hsa_TTC3_0022700 | Exon-Exon | chr21:38528957-38534365 | chr21:37156655-37162063 | 484 nt | 0.3822 |
| hsa_TTC3_0022900 | Exon-Exon | chr21:38528957-38536517 | chr21:37156655-37164215 | 252 nt | 0.3849 |
| hsa_TTC3_0022800 | Exon-Exon | chr21:38528957-38539922 | chr21:37156655-37167620 | 1727 nt | 0.4152 |
| hsa_TTC3_0022300 | Exon-Exon | chr21:38528957-38568337 | chr21:37156655-37196036 | 2839 nt | 0.4244 |
| hsa_TTC3_0022400 | Exon-Exon | chr21:38528957-38570326 | chr21:37156655-37198025 | 250 nt | 0.3880 |
| hsa_chr21_0074500 | Intergenic-Intergenic | chr21:38529274-38531444 | chr21:37156972-37159142 | 2171 nt | 0.3878 |
| hsa_TTC3_0023000 | Exon-Exon | chr21:38529463-38536517 | chr21:37157161-37164215 | 397 nt | 0.3929 |
| hsa_TTC3_0023400 | Exon-Exon | chr21:38532001-38545046 | chr21:37159699-37172744 | 197 nt | 0.4162 |
Showing 241 to 250 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].