Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0023500 | Exon-Exon | chr21:38532001-38555215 | chr21:37159699-37182913 | 187 nt | 0.3476 |
| hsa_TTC3_0023300 | Exon-Exon | chr21:38532001-38570241 | chr21:37159699-37197940 | 2773 nt | 0.4284 |
| hsa_TTC3_0023600 | Exon-Exon | chr21:38533119-38534352 | chr21:37160817-37162050 | 103 nt | 0.3495 |
| hsa_TTC3_0023700 | Exon-Exon | chr21:38534292-38536517 | chr21:37161990-37164215 | 239 nt | 0.4017 |
| hsa_TTC3_0023800 | Exon-Exon | chr21:38534292-38539922 | chr21:37161990-37167620 | 1371 nt | 0.4216 |
| hsa_TTC3_0024100 | Exon-Exon | chr21:38536353-38555215 | chr21:37164051-37182913 | 1587 nt | 0.4102 |
| hsa_TTC3_0024200 | Exon-Exon | chr21:38537852-38538917 | chr21:37165550-37166615 | 1066 nt | 0.4296 |
| hsa_TTC3_0024300 | Exon-Exon | chr21:38537852-38539922 | chr21:37165550-37167620 | 1132 nt | 0.4258 |
| hsa_TTC3_0024400 | Exon-Exon | chr21:38537852-38545046 | chr21:37165550-37172744 | 150 nt | 0.3933 |
| hsa_chr21_0074600 | Intergenic-Intergenic | chr21:38537977-38538207 | chr21:37165675-37165905 | 231 nt | 0.3853 |
Showing 251 to 260 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].