Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0025300 | Exon-Exon | chr21:38538491-38555195 | chr21:37166189-37182893 | 763 nt | 0.4063 |
| hsa_TTC3_0025400 | Exon-Exon | chr21:38538538-38538917 | chr21:37166236-37166615 | 380 nt | 0.4500 |
| hsa_chr21_0074900 | Intergenic-Intergenic | chr21:38538566-38538718 | chr21:37166264-37166416 | 153 nt | 0.4641 |
| hsa_chr21_0075000 | Intergenic-Intergenic | chr21:38538568-38538734 | chr21:37166266-37166432 | 167 nt | 0.4611 |
| hsa_TTC3_0025500 | Exon-Exon | chr21:38538696-38538896 | chr21:37166394-37166594 | 201 nt | 0.4328 |
| hsa_chr21_0075100 | Intergenic-Intergenic | chr21:38538794-38539905 | chr21:37166492-37167603 | 173 nt | 0.3988 |
| hsa_TTC3_0025600 | Exon-Exon | chr21:38539857-38545046 | chr21:37167555-37172744 | 216 nt | 0.3843 |
| hsa_TTC3_0025700 | Exon-Exon | chr21:38539857-38563725 | chr21:37167555-37191424 | 714 nt | 0.3739 |
| hsa_TTC3_0026000 | Exon-Exon | chr21:38544897-38555215 | chr21:37172595-37182913 | 150 nt | 0.3933 |
| hsa_TTC3_0025800 | Exon-Exon | chr21:38544897-38558075 | chr21:37172595-37185774 | 359 nt | 0.3538 |
Showing 271 to 280 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].