Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0025900 | Exon-Exon | chr21:38544897-38560896 | chr21:37172595-37188595 | 557 nt | 0.3770 |
| hsa_TTC3_0026100 | Exon-Exon | chr21:38544999-38559446 | chr21:37172697-37187145 | 48 nt | 0.4375 |
| hsa_TTC3_0026200 | Intron-Intron | chr21:38554661-38554858 | chr21:37182359-37182556 | 198 nt | 0.4040 |
| hsa_TTC3_0026400 | Exon-Exon | chr21:38555076-38560896 | chr21:37182774-37188595 | 407 nt | 0.3710 |
| hsa_TTC3_0026500 | Exon-Exon | chr21:38555076-38563725 | chr21:37182774-37191424 | 498 nt | 0.3695 |
| hsa_TTC3_0026600 | Exon-Exon | chr21:38555076-38570326 | chr21:37182774-37198025 | 146 nt | 0.3014 |
| hsa_chr21_0075200 | Intergenic-Intergenic | chr21:38555982-38556253 | chr21:37183680-37183951 | 272 nt | 0.4596 |
| hsa_TTC3_0026700 | Exon-Exon | chr21:38558007-38563725 | chr21:37185706-37191424 | 358 nt | 0.3966 |
| hsa_TTC3_0026800 | Exon-Exon | chr21:38558007-38564514 | chr21:37185706-37192213 | 460 nt | 0.3935 |
| hsa_TTC3_0027200 | Exon-Exon | chr21:38559350-38560896 | chr21:37187049-37188595 | 107 nt | 0.4673 |
Showing 281 to 290 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].