Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0010200 | Exon-Exon | chr21:38480692-38498443 | chr21:37108392-37126143 | 452 nt | 0.4027 |
| hsa_TTC3_0010300 | Exon-Exon | chr21:38480692-38501363 | chr21:37108392-37129063 | 513 nt | 0.3957 |
| hsa_TTC3_0010400 | Exon-Exon | chr21:38480692-38505066 | chr21:37108392-37132766 | 598 nt | 0.3963 |
| hsa_TTC3_0010500 | Exon-Exon | chr21:38480692-38507814 | chr21:37108392-37135514 | 733 nt | 0.3997 |
| hsa_TTC3_0010600 | Exon-Exon | chr21:38480692-38511014 | chr21:37108392-37138714 | 814 nt | 0.4042 |
| hsa_TTC3_0010700 | Exon-Exon | chr21:38480692-38512973 | chr21:37108392-37140673 | 927 nt | 0.4024 |
| hsa_TTC3_0010800 | Exon-Exon | chr21:38480692-38519903 | chr21:37108392-37147603 | 1171 nt | 0.3988 |
| hsa_TTC3_0010900 | Exon-Exon | chr21:38480692-38520947 | chr21:37108392-37148647 | 1273 nt | 0.3928 |
| hsa_TTC3_0011000 | Exon-Exon | chr21:38480692-38524329 | chr21:37108392-37152029 | 1568 nt | 0.3858 |
| hsa_TTC3_0011100 | Exon-Exon | chr21:38480692-38525577 | chr21:37108392-37153277 | 1895 nt | 0.3831 |
Showing 21 to 30 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].