Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0011200 | Exon-Exon | chr21:38480692-38534365 | chr21:37108392-37162063 | 2325 nt | 0.3841 |
| hsa_TTC3_0011300 | Exon-Exon | chr21:38480692-38536517 | chr21:37108392-37164215 | 2490 nt | 0.3859 |
| hsa_TTC3_0011400 | Exon-Exon | chr21:38480692-38568337 | chr21:37108392-37196036 | 250 nt | 0.3640 |
| hsa_TTC3_0011500 | Exon-Exon | chr21:38480692-38573871 | chr21:37108392-37201570 | 250 nt | 0.4080 |
| hsa_TTC3_0014500 | Exon-Exon | chr21:38494117-38507814 | chr21:37121817-37135514 | 678 nt | 0.3953 |
| hsa_TTC3_0014600 | Exon-Exon | chr21:38494117-38512973 | chr21:37121817-37140673 | 872 nt | 0.3991 |
| hsa_chr21_0073900 | Intergenic-Intergenic | chr21:38495731-38495994 | chr21:37123431-37123694 | 264 nt | 0.3598 |
| hsa_TTC3_0016100 | Exon-Exon | chr21:38496919-38505066 | chr21:37124619-37132766 | 334 nt | 0.3952 |
| hsa_TTC3_0016200 | Exon-Exon | chr21:38496919-38511014 | chr21:37124619-37138714 | 550 nt | 0.4073 |
| hsa_TTC3_0016300 | Exon-Exon | chr21:38496919-38575408 | chr21:37124619-37203107 | 250 nt | 0.2840 |
Showing 31 to 40 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].