Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0017100 | Exon-Exon | chr21:38501303-38507814 | chr21:37129003-37135514 | 281 nt | 0.3950 |
| hsa_TTC3_0017300 | Exon-Exon | chr21:38504982-38511014 | chr21:37132682-37138714 | 301 nt | 0.4186 |
| hsa_TTC3_0017400 | Exon-Exon | chr21:38504982-38512973 | chr21:37132682-37140673 | 414 nt | 0.4106 |
| hsa_TTC3_0020500 | Exon-Exon | chr21:38519781-38519903 | chr21:37147481-37147603 | 123 nt | 0.3902 |
| hsa_TTC3_0020600 | Exon-Exon | chr21:38519781-38520947 | chr21:37147481-37148647 | 225 nt | 0.3600 |
| hsa_TTC3_0020800 | Exon-Exon | chr21:38519781-38524329 | chr21:37147481-37152029 | 520 nt | 0.3577 |
| hsa_TTC3_0021300 | Exon-Exon | chr21:38522378-38523184 | chr21:37150078-37150884 | 158 nt | 0.3671 |
| hsa_TTC3_0021400 | Exon-Exon | chr21:38522378-38525577 | chr21:37150078-37153277 | 622 nt | 0.3633 |
| hsa_TTC3_0021500 | Exon-Exon | chr21:38523120-38575408 | chr21:37150820-37203107 | 250 nt | 0.2680 |
| hsa_TTC3_0021600 | Exon-Exon | chr21:38524193-38560896 | chr21:37151893-37188595 | 2748 nt | 0.3985 |
Showing 41 to 50 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].