Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0022200 | Exon-Exon | chr21:38528957-38545046 | chr21:37156655-37172744 | 1877 nt | 0.4134 |
| hsa_TTC3_0023100 | Exon-Exon | chr21:38532001-38536517 | chr21:37159699-37164215 | 343 nt | 0.4023 |
| hsa_TTC3_0023200 | Exon-Exon | chr21:38532001-38568337 | chr21:37159699-37196036 | 2587 nt | 0.4283 |
| hsa_TTC3_0023900 | Exon-Exon | chr21:38536353-38539922 | chr21:37164051-37167620 | 1297 nt | 0.4241 |
| hsa_TTC3_0024000 | Exon-Exon | chr21:38536353-38545046 | chr21:37164051-37172744 | 1447 nt | 0.4209 |
| hsa_TTC3_0026900 | Exon-Exon | chr21:38559350-38568337 | chr21:37187049-37196036 | 753 nt | 0.4794 |
| hsa_chr21_0075300 | Intergenic-Intergenic | chr21:38559569-38559685 | chr21:37187268-37187384 | 117 nt | 0.3504 |
| hsa_TTC3_0027700 | Exon-Exon | chr21:38567976-38575408 | chr21:37195675-37203107 | 2394 nt | 0.4440 |
| hsa_chr21_0073200 | Intergenic-Intergenic | chr21:38445709-38448975 | chr21:37073409-37076675 | 250 nt | 0.4520 |
| hsa_TTC3_0000100 | Intron-Intron | chr21:38446886-38447341 | chr21:37074586-37075041 | 456 nt | 0.3684 |
Showing 51 to 60 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].