Basic Information

Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3 RNF105 DCRR1 TPRDIII TPRD RING-Type E3 Ubiquitin Transferase TTC3 Tetratricopeptide Repeat Protein 3 E3 Ubiquitin-Protein Ligase TTC3 RING Finger Protein 105 TPR Repeat Protein 3 TPR Repeat Protein D TPRDII TPRDI Protein DCRR1 EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408 UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
UCSC Genome Browser Search in Marker Scope
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation Sudden cardiac death diagnosis
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_TTC3_0000200 Intron-Exon-Intron chr21:38448236-38466390 chr21:37075936-37094090 250 nt 0.2240
hsa_TTC3_0000300 Intron-Exon-Intron chr21:38448236-38467744 chr21:37075936-37095444 250 nt 0.2280
hsa_TTC3_0000400 Intron-Exon-Intron chr21:38448236-38468943 chr21:37075936-37096643 250 nt 0.2520
hsa_TTC3_0000500 Intron-Exon chr21:38448236-38470460 chr21:37075936-37098160 250 nt 0.2880
hsa_TTC3_0000600 Intron-Exon chr21:38448236-38470512 chr21:37075936-37098212 250 nt 0.2720
hsa_TTC3_0000700 Intron-Exon-Intron chr21:38448236-38472048 chr21:37075936-37099748 250 nt 0.2600
hsa_TTC3_0000800 Intron-Intron chr21:38448283-38448555 chr21:37075983-37076255 273 nt 0.3150
hsa_TTC3_0000900 Intron-Exon-Intron chr21:38448343-38468943 chr21:37076043-37096643 250 nt 0.2720
hsa_TTC3_0001000 Intron-Intron chr21:38452779-38455676 chr21:37080479-37083376 2898 nt 0.3841
hsa_chr21_0073300 Intergenic-Intergenic chr21:38452989-38453283 chr21:37080689-37080983 295 nt 0.3017
Showing 61 to 70 of 299 entries
Forensic Context

A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].