Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0001300 | Exon-Exon | chr21:38456309-38480746 | chr21:37084009-37108446 | 1234 nt | 0.3841 |
| hsa_TTC3_0001100 | Exon-Exon | chr21:38456309-38545046 | chr21:37084009-37172744 | 250 nt | 0.2920 |
| hsa_TTC3_0001200 | Exon-Exon | chr21:38456309-38564514 | chr21:37084009-37192213 | 250 nt | 0.2920 |
| hsa_chr21_0073400 | Intergenic-Intergenic | chr21:38456451-38456603 | chr21:37084151-37084303 | 153 nt | 0.4706 |
| hsa_TTC3_0001400 | Exon-Exon | chr21:38456456-38462586 | chr21:37084156-37090286 | 667 nt | 0.4108 |
| hsa_TTC3_0001500 | Exon-Exon | chr21:38456528-38463713 | chr21:37084228-37091413 | 716 nt | 0.3883 |
| hsa_TTC3_0001600 | Exon-Intron | chr21:38456561-38458002 | chr21:37084261-37085702 | 1442 nt | 0.4300 |
| hsa_TTC3_0001800 | Exon-Exon | chr21:38458143-38458372 | chr21:37085843-37086072 | 230 nt | 0.3652 |
| hsa_TTC3_0001900 | Exon-Exon | chr21:38459529-38463713 | chr21:37087229-37091413 | 630 nt | 0.3714 |
| hsa_TTC3_0004400 | Exon-Intron | chr21:38459547-38461200 | chr21:37087247-37088900 | 108 nt | 0.3519 |
Showing 71 to 80 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].