Basic Information
Symbol
circTTC3
RNA Class
circRNA
Alias
Tetratricopeptide Repeat Domain 3
RNF105
DCRR1
TPRDIII
TPRD
RING-Type E3 Ubiquitin Transferase TTC3
Tetratricopeptide Repeat Protein 3
E3 Ubiquitin-Protein Ligase TTC3
RING Finger Protein 105
TPR Repeat Protein 3
TPR Repeat Protein D
TPRDII
TPRDI
Protein DCRR1
EC 2.3.2.27
Location (GRCh37)
21:38445709-38575408
UCSC Genome Browser
Location (GRCh38)
21:37073409-37203107
Host gene
TTC3
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_TTC3_0004500 | Exon-Exon | chr21:38459547-38462586 | chr21:37087247-37090286 | 155 nt | 0.4452 |
| hsa_TTC3_0003800 | Exon-Exon | chr21:38459547-38497042 | chr21:37087247-37124742 | 1244 nt | 0.3698 |
| hsa_TTC3_0003900 | Exon-Exon | chr21:38459547-38498443 | chr21:37087247-37126143 | 1308 nt | 0.3746 |
| hsa_TTC3_0004700 | Exon-Exon | chr21:38459547-38505066 | chr21:37087247-37132766 | 155 nt | 0.4452 |
| hsa_TTC3_0004000 | Exon-Exon | chr21:38459547-38507814 | chr21:37087247-37135514 | 1589 nt | 0.3782 |
| hsa_TTC3_0004100 | Exon-Exon | chr21:38459547-38511014 | chr21:37087247-37138714 | 1670 nt | 0.3814 |
| hsa_TTC3_0004200 | Exon-Exon | chr21:38459547-38512973 | chr21:37087247-37140673 | 1783 nt | 0.3819 |
| hsa_TTC3_0004300 | Exon-Exon | chr21:38459547-38516945 | chr21:37087247-37144645 | 1904 nt | 0.3818 |
| hsa_TTC3_0004800 | Exon-Exon | chr21:38459547-38520947 | chr21:37087247-37148647 | 155 nt | 0.4452 |
| hsa_TTC3_0002900 | Exon-Exon | chr21:38459547-38522470 | chr21:37087247-37150170 | 2222 nt | 0.3794 |
Showing 81 to 90 of 299 entries
Forensic Context
A study in humans demonstrated that the circTTC3 shows a significant decrease in the peripheral blood of Alzheimer's disease patients, suggesting its potential to distinguish this condition from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. In mice and rats, circTTC3 was markedly upregulated in ischemic myocardium post-myocardial infarction and counteracted hypoxia-induced ATP depletion and apoptotic death in cardiomyocytes via the miR-15b/Arl2 axis [Tian et al. DOI:10.3390/molecules26041155]. It also alleviated hypoxic injury in HaCaT cells via miR-449a/NF-κB and PI3K/AKT pathways [Huang et al. DOI:10.3390/cells11091381].