Basic Information
Symbol
circATXN2
RNA Class
circRNA
Alias
Ataxin 2
ATX2
TNRC13
SCA2
Trinucleotide Repeat-Containing Gene 13 Protein
Spinocerebellar Ataxia Type 2 Protein
Ataxin-2
Spinocerebellar Ataxia 2 (Olivopontocerebellar Ataxia 2, Autosomal Dominant, Ataxin 2)
Trinucleotide Repeat Containing 13
Location (GRCh37)
12:111958686-111963120
UCSC Genome Browser
Location (GRCh38)
12:111520882-111525316
Host gene
ATXN2
Host category
mRNA
Forensic tag(s)
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_ATXN2_0020500 | Exon-Exon | chr12:111958686-111963120 | chr12:111520882-111525316 | 217 nt | 0.4147 |
Forensic Context
A study in mice demonstrated that the circATXN2 sponges miR-181a to increase SIRT1 expression, thereby promoting glioma oncogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. A study in humans identified 736 differentially expressed circular RNAs in peripheral blood from ischemic stroke patients, with the circATXN2 showing upregulation and diagnostic potential validated by qRT-PCR and ROC curve analysis (AUC=0.800) [Wei et al. DOI:10.1186/s12883-021-02397-0]. CircRNAs are abundant in biofluids like blood and saliva, supporting their potential as clinical biomarkers for various diseases [Lee et al. DOI:10.1016/j.biopha.2018.12.052].