Basic Information
Symbol
circUBASH3B
RNA Class
circRNA
Alias
Ubiquitin Associated And SH3 Domain Containing B
TULA-2
STS-1
T-Cell Ubiquitin Ligand 2
KIAA1959
TULA2
SH3 Domain-Containing 70 KDa Protein, Suppressor Of T-Cell Receptor Signaling 1, Nm23-Phosphorylated Unknown Substrate
Ubiquitin-Associated And SH3 Domain-Containing Protein B
Suppressor Of T-Cell Receptor Signaling 1
Tyrosine-Protein Phosphatase STS1/TULA2
Cbl-Interacting Protein P70
STS1
Nm23-Phosphorylated Unknown Substrate
Cbl-Interacting Protein Sts-1
EC 3.1.3.48
P70
Location (GRCh37)
11:122646927-122647918
UCSC Genome Browser
Location (GRCh38)
11:122776219-122777210
Host gene
UBASH3B
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_UBASH3B_0002500 | Exon-Exon | chr11:122646927-122647918 | chr11:122776219-122777210 | 241 nt | 0.5560 |
Forensic Context
A study in humans demonstrated that circUBASH3B is specifically expressed in cerebrospinal fluid exosomes and serves as a biomarker for immune-mediated demyelinating disease [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in humans demonstrated that circUBASH3B is significantly decreased in the peripheral blood of Alzheimer's disease patients and may be used to distinguish AD from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. Further research in humans identified this circulating peripheral blood circRNA as being associated with Alzheimer's disease, reinforcing its potential role as a biomarker [Daws et al. DOI:10.1016/j.mcn.2023.103841].