Basic Information
Symbol
circUSP14
RNA Class
circRNA
Alias
Ubiquitin Specific Peptidase 14
TGT
Ubp6
Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase)
Ubiquitin Specific Protease 14 (TRNA-Guanine Transglycosylase)
Ubiquitin Carboxyl-Terminal Hydrolase 14
Deubiquitinating Enzyme 14
Ubiquitin Thioesterase 14
TRNA-Guanine Transglycosylase, 60-KD Subunit
Ubiquitin-Specific Processing Protease 14
Ubiquitin-Specific-Processing Protease 14
Ubiquitin Thiolesterase 14
EC 3.4.19.12
EC 3.1.2.15
Location (GRCh37)
18:196637-199316
UCSC Genome Browser
Location (GRCh38)
18:196637-199316
Host gene
USP14
Host category
mRNA
Forensic tag(s)
Sudden death from CNS diseases
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_USP14_0004300 | Exon-Exon | chr18:196637-199316 | chr18:196637-199316 | 413 nt | 0.3801 |
Forensic Context
A study in humans demonstrated that the circUSP14 is a diagnostic biomarker, being up-regulated in the peripheral whole blood of ischemic stroke patients compared to healthy controls, with its expression validated by qRT-PCR [Wei et al. DOI:10.1186/s12883-021-02397-0]. Receiver operating characteristic curve analysis indicated the circUSP14 has a relatively high diagnostic value for ischemic stroke, with an area under the curve of 0.809.