Basic Information
Symbol
circWDR37
RNA Class
circRNA
Alias
WD Repeat Domain 37
KIAA0982
WD Repeat-Containing Protein 37
NOCGUS
Location (GRCh37)
10:1125951-1126416
UCSC Genome Browser
Location (GRCh38)
10:1080011-1080476
Host gene
WDR37
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_WDR37_0005300 | Exon-Exon | chr10:1125951-1126416 | chr10:1080011-1080476 | 161 nt | 0.4845 |
Forensic Context
A study in humans demonstrated that circWDR37 is specifically expressed in peripheral blood and its levels significantly decrease in patients with Alzheimer's disease, potentially distinguishing it from other dementias [Misir et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circWDR37 is significantly lower in acute myeloid leukemia (AML) patients compared to healthy controls, and its restoration is associated with successful chemotherapy treatment and patients entering complete remission [Lee et al. DOI:10.1016/j.biopha.2018.12.052][Di Agostino et al. DOI:10.3389/fcell.2020.00389].