Basic Information

Symbol
circXPO1
RNA Class
circRNA
Alias
Exportin 1 CRM1 CRM-1 Emb Chromosome Region Maintenance 1 Protein Homolog Exportin 1 (CRM1 Homolog, Yeast) Exportin-1 Exp1 Exportin-1 (Required For Chromosome Region Maintenance) Chromosome Region Maintenance 1 Homolog (Yeast) Chromosome Region Maintenance 1 Homolog Exportin 1 (CRM1, Yeast, Homolog)
Location (GRCh37)
2:61605498-61765418 UCSC Genome Browser
Location (GRCh38)
2:61378363-61538283
UCSC Genome Browser Search in Marker Scope
Host gene
XPO1
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_XPO1_0022300 Intron-Intron chr2:61730648-61731152 chr2:61503513-61504017 505 nt 0.5347
hsa_XPO1_0022400 Intron-Intron chr2:61730862-61734104 chr2:61503727-61506969 250 nt 0.3520
hsa_XPO1_0022500 Intron-Intron chr2:61730862-61735238 chr2:61503727-61508103 250 nt 0.3560
hsa_chr2_0891700 Intergenic-Intergenic chr2:61732789-61737347 chr2:61505654-61510212 250 nt 0.3800
hsa_chr2_0891800 Intergenic-Intergenic chr2:61732974-61737183 chr2:61505839-61510048 250 nt 0.3200
hsa_XPO1_0022600 Intron-Intron chr2:61734936-61736245 chr2:61507801-61509110 1310 nt 0.3863
hsa_chr2_0891900 Intergenic-Intergenic chr2:61737616-61737791 chr2:61510481-61510656 176 nt 0.3182
hsa_chr2_0892000 Intergenic-Intergenic chr2:61737859-61741996 chr2:61510724-61514861 250 nt 0.3960
hsa_chr2_0892100 Intergenic-Intergenic chr2:61738516-61741996 chr2:61511381-61514861 250 nt 0.4000
hsa_XPO1_0022700 Intron-Intron chr2:61738982-61741700 chr2:61511847-61514565 2719 nt 0.4410
Showing 241 to 250 of 290 entries
Forensic Context

A study in humans demonstrated that circXPO1 is highly expressed in early stages of hepatocellular carcinoma, bladder cancers, and breast cancer, and its decreased expression in myocardial tissues is associated with improved cardiac function after acute myocardial infarction [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in human coronary artery samples from a single autopsy case demonstrated that circXPO1 was identified as a co-overexpressed circRNA in both the left anterior descending and right coronary artery samples, classifying it as a potential biomarker associated with coronary atherosclerosis [Hou et al. DOI:10.1002/jcla.23552].