Forensic RNA Knowledge Base

Basic Information

Symbol

circXRCC6BP1

RNA Class

circRNA

Alias

ATP23 Metallopeptidase And ATP Synthase Assembly Factor Homolog KUB3 XRCC6BP1 Mitochondrial Inner Membrane Protease ATP23 Homolog XRCC6-Binding Protein 1 Ku70-Binding Protein 3 ATP23 Metallopeptidase And ATP Synthase Assembly Factor Homolog (S. Cerevisiae) XRCC6 Binding Protein 1 Ku70 Binding Protein 3 EC 3.4.24.- EC 3.4.24

Location (GRCh37)

12:58340778-58347472 UCSC Genome Browser

Location (GRCh38)

12:57946995-57953689

UCSC Genome Browser Search in Marker Scope

Host gene

XRCC6BP1

Host category

mRNA

Forensic tag(s)

Sudden death from CNS diseases

External database

circbank

Transcripts

ID	Type	Location (GRCh37)	Location (GRCh38)	Length	GC content
hsa_XRCC6BP1_0000800	Exon-Exon	chr12:58340778-58347472	chr12:57946995-57953689	304 nt	0.4178

Forensic Context

A study in mice demonstrated that circXRCC6BP1 is highly expressed in brain tissue and plays a crucial role in neuronal function and development [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in humans identified 736 differentially expressed circular RNAs in peripheral blood from ischemic stroke patients, with the circXRCC6BP1 being up-regulated (log2FC=2.298732) and derived from the host gene ATP23 [Wei et al. DOI:10.1186/s12883-021-02397-0].