Basic Information
Symbol
circZMPSTE24
RNA Class
circRNA
Alias
Zinc Metallopeptidase STE24
FACE-1
STE24
CAAX Prenyl Protease 1 Homolog
Ste24p
HGPS
PRO1
Farnesylated Proteins-Converting Enzyme 1
Prenyl Protein-Specific Endoprotease 1
Zinc Metalloproteinase Ste24 Homolog
FACE1
Zinc Metallopeptidase STE24 Homolog (S. Cerevisiae)
Zinc Metalloproteinase (STE24 Homolog, Yeast)
Zinc Metallopeptidase (STE24 Homolog, Yeast)
Hutchinson-Gilford Progeria Syndrome
Zinc Metallopeptidase STE24 Homolog
EC 3.4.24.84
RSDM1
Location (GRCh37)
1:40733458-40737707
UCSC Genome Browser
Location (GRCh38)
1:40267786-40272035
Host gene
ZMPSTE24
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_ZMPSTE24_0001600 | Exon-Exon | chr1:40733458-40737707 | chr1:40267786-40272035 | 499 nt | 0.3868 |
Forensic Context
A study in mice demonstrated that the circZMPSTE24 is highly expressed in the brain and cerebellum, where it regulates neuronal plasticity and structural changes at the synapse during development [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in human coronary artery segments from an autopsy case demonstrated that the circZMPSTE24 was differentially expressed across coronary arteries and validated as a potential biomarker via qRT-PCR, with its expression showing notable differences compared to the left main trunk segment [Hou et al. DOI:10.1002/jcla.23552].