Forensic Context

A study in mice demonstrated that the circZNF292 is hypoxia-induced and regulates Wnt/β-catenin pathway components to promote glioma proliferation and tube formation [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746]. In rat models of myocardial ischemia, the circZNF292 was highly expressed following oxygen glucose deprivation treatment, and its overexpression was shown to release OGD-induced damage [Tian et al. DOI:10.3390/molecules26041155]. A study in human hepatoma cells demonstrated that the circZNF292 promotes hypoxic cell proliferation, vasculogenic mimicry, and radioresistance via the Wnt/β-catenin pathway, and induces tube formation and spheroid sprouting in endothelial cells [Huang et al. DOI: 10.3390/cells11091381]. Research in human glioma cells further showed that the circZNF292 is hypoxia-induced and regulates Wnt/β-catenin pathway components to promote proliferation and tube formation [Mehta et al. DOI: 10.1016/j.pneurobio.2020.101746].