| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_BIRC6_0028200 | Intron-Exon-Intron | chr2:32660197-32660653 | chr2:32435129-32435585 | 457 nt | 0.3479 |
| hsa_BIRC6_0028800 | Intron-Exon-Intron | chr2:32660522-32664754 | chr2:32435454-32439686 | 443 nt | 0.4244 |
| hsa_BIRC6_0028900 | Intron-Exon-Intron | chr2:32660522-32670736 | chr2:32435454-32445668 | 280 nt | 0.4250 |
| hsa_BIRC6_0029000 | Intron-Exon-Intron | chr2:32660522-32679010 | chr2:32435454-32453942 | 138 nt | 0.4203 |
| hsa_BIRC6_0029100 | Intron-Exon-Intron | chr2:32660522-32679022 | chr2:32435454-32453954 | 132 nt | 0.4242 |
| hsa_BIRC6_0028400 | Intron-Exon-Intron | chr2:32660522-32693851 | chr2:32435454-32468783 | 2760 nt | 0.4330 |
| hsa_BIRC6_0029200 | Intron-Exon-Intron | chr2:32660522-32696192 | chr2:32435454-32471124 | 266 nt | 0.4060 |
| hsa_BIRC6_0029300 | Intron-Exon-Intron | chr2:32660522-32696219 | chr2:32435454-32471151 | 264 nt | 0.4242 |
| hsa_BIRC6_0028500 | Intron-Exon-Intron | chr2:32660522-32728303 | chr2:32435454-32503236 | 250 nt | 0.3440 |
| hsa_BIRC6_0028600 | Intron-Exon-Intron | chr2:32660522-32730272 | chr2:32435454-32505205 | 250 nt | 0.3600 |
A study in human embryonic stem cells demonstrated that the circBIRC6 controls pluripotency by sequestering miR-34 and miR-145 [Patop et al. DOI:10.15252/embj.2018100836], and it acts as a sponge for miR-34a and miR-145 to relieve the suppression of NANOG, OCT4, and SOX2 expression [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. A study in humans demonstrated that the BIRC6 gene can generate hundreds of circRNA isoforms, and their expression changes during tumorigenesis can differ [Li et al. DOI:10.1093/bib/bby006].