| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_chr2_0736000 | Intergenic-Intergenic | chr2:32788901-32795499 | chr2:32563834-32570432 | 250 nt | 0.3840 |
| hsa_BIRC6_0103000 | Intron-Intron | chr2:32789081-32792093 | chr2:32564014-32567026 | 250 nt | 0.3240 |
| hsa_chr2_0736100 | Intergenic-Intergenic | chr2:32793650-32795499 | chr2:32568583-32570432 | 1850 nt | 0.4135 |
| hsa_BIRC6_0103100 | Intron-Intron | chr2:32793847-32794107 | chr2:32568780-32569040 | 261 nt | 0.4291 |
| hsa_BIRC6_0103200 | Intron-Intron | chr2:32796067-32796269 | chr2:32571000-32571202 | 203 nt | 0.3842 |
| hsa_BIRC6_0103300 | Intron-Exon-Intron | chr2:32799369-32800433 | chr2:32574302-32575366 | 1065 nt | 0.4545 |
| hsa_BIRC6_0103600 | Exon-Exon | chr2:32800223-32800433 | chr2:32575156-32575366 | 211 nt | 0.4692 |
| hsa_BIRC6_0103500 | Intron-Exon-Intron | chr2:32800223-32809904 | chr2:32575156-32584837 | 250 nt | 0.3680 |
| hsa_BIRC6_0103700 | Exon-Exon | chr2:32800223-32820211 | chr2:32575156-32595144 | 468 nt | 0.4274 |
| hsa_BIRC6_0103800 | Exon-Exon | chr2:32800223-32823035 | chr2:32575156-32597968 | 859 nt | 0.4424 |
A study in human embryonic stem cells demonstrated that the circBIRC6 controls pluripotency by sequestering miR-34 and miR-145 [Patop et al. DOI:10.15252/embj.2018100836], and it acts as a sponge for miR-34a and miR-145 to relieve the suppression of NANOG, OCT4, and SOX2 expression [Di Agostino et al. DOI:10.3389/fcell.2020.00389]. A study in humans demonstrated that the BIRC6 gene can generate hundreds of circRNA isoforms, and their expression changes during tumorigenesis can differ [Li et al. DOI:10.1093/bib/bby006].