Basic Information
Symbol
circCACNA1C
RNA Class
circRNA
Alias
Calcium Voltage-Gated Channel Subunit Alpha1 C
CACH2
CACN2
CACNL1A1
CCHL1A1
Cav1.2
LQT8
TS
Calcium Channel, Voltage-Dependent, L Type, Alpha 1C Subunit
Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C
CACNA1C Intronic Transcript 2 (Non-Protein Coding)
CACNA1C Intronic Transcript 2
CACNA1C-IT2
Calcium Channel, L Type, Alpha-1 Polypeptide, Isoform 1, Cardiac Muscle
Calcium Channel, Cardic Dihydropyridine-Sensitive, Alpha-1 Subunit
Voltage-Dependent L-Type Ca2+ Channel Alpha 1 Subunit
Voltage-Gated Calcium Channel Subunit Alpha Cav1.2
DHPR, Alpha-1 Subunit
TS. LQT8
NEDHLSS
Location (GRCh37)
12:2224390-2229596
UCSC Genome Browser
Location (GRCh38)
12:2115224-2120430
Host gene
CACNA1C
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_CACNA1C_0003600 | Exon-Exon | chr12:2224390-2229596 | chr12:2115224-2120430 | 428 nt | 0.5911 |
Forensic Context
A study in humans demonstrated that the circCACNA1C was upregulated in the plasma of patients with newly onset atrial fibrillation after coronary-artery bypass grafting, showing a positive correlation with fasting blood glucose and achieving an area under the curve of 0.802 with a sensitivity of 0.794 and a specificity of 0.776 for diagnosis [Tian et al. DOI:10.3390/molecules26041155].