Basic Information
Symbol
circCCNB1
RNA Class
circRNA
Alias
Cyclin B1
CCNB
G2/Mitotic-Specific Cyclin-B1
G2/Mitotic-Specific Cyclin B1
Location (GRCh37)
5:68411064-68474070
UCSC Genome Browser
Location (GRCh38)
5:69115237-69178243
Host gene
CCNB1
Host category
mRNA
Forensic tag(s)
Chronological age estimation
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_CCNB1_0001400 | Exon-Exon | chr5:68470078-68473176 | chr5:69174251-69177349 | 648 nt | 0.4244 |
| hsa_CCNB1_0001900 | Exon-Exon | chr5:68470704-68471356 | chr5:69174877-69175529 | 237 nt | 0.4219 |
| hsa_CCNB1_0002100 | Exon-Exon | chr5:68471224-68473176 | chr5:69175397-69177349 | 252 nt | 0.4087 |
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Forensic Context
A study in humans demonstrated that the circCCNB1 can serve as a biomarker for forensic age prediction, where its expression was analyzed in peripheral blood samples from 100 individuals aged 19-73 years [Wang et al. DOI:10.3389/fgene.2022.825443]. Furthermore, a separate review highlighted that the circCCNB1 interacts with CCNB1 and CDK1 proteins, dissociating the CCNB1/CDK1 complex and resulting in a loss-of-function effect on tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7].