Basic Information
Symbol
circCOG2
RNA Class
circRNA
Alias
Component Of Oligomeric Golgi Complex 2
LDLC
Low Density Lipoprotein Receptor Defect C-Complementing Protein
Low Density Lipoprotein Receptor Defect C Complementing
Conserved Oligomeric Golgi Complex Subunit 2
COG Complex Subunit 2
Brefeldin A-Sensitive, Peripheral Golgi Protein
Conserved Oligomeric Golgi Complex Protein 2
CDG2Q
Location (GRCh37)
1:230798887-230810870
UCSC Genome Browser
Location (GRCh38)
1:230663141-230675124
Host gene
COG2
Host category
mRNA
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_COG2_0002300 | Exon-Exon | chr1:230798887-230810870 | chr1:230663141-230675124 | 726 nt | 0.4298 |
Forensic Context
A study in human coronary artery samples from a single autopsy case demonstrated that the circCOG2 was validated by qRT-PCR and Sanger sequencing, showing significantly subtler expression levels in the proximal and mid segments of the left anterior descending artery compared to the left main trunk, which had more severe atherosclerosis [Hou et al. DOI:10.1002/jcla.23552]. This circRNA is suggested to play a pathological role in coronary atherosclerosis and may serve as a diagnostic or therapeutic target for coronary artery disease.