Basic Information

Symbol
hsa-mir-1228
RNA class
miRNA miRNA hairpin
Alias
MIR1228 MicroRNA 1228 Hsa-MiR-1228-5p Hsa-Mir-1228 MIRN1228 Hsa-MiR-1228-3p MIMAT0005582 MIMAT0005583 MI0006318 Mir-1228
Location (GRCh38)
10:14436576-14436661
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-1228
Sequence length
73 nt
GC content
0.7534

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-44.30 kcal/mol
Thermodynamic ensemble
Free energy: -46.51 kcal/mol
Frequency: 0.0278
Diversity: 12.59
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((((.((((((((.((........(.(((((.....))))).))).)))))))))))))))).....
Thermodynamic Ensemble Prediction
,.(((((((((((((((((.,,.,,,,...{.(((((.....)))))}))),)))))))))))))))).....
Forensic Context

A study in humans demonstrated that the mir-1228 is upregulated with age in peripheral whole blood samples, showing a significant positive correlation with chronological age [Wang et al. DOI:10.3389/fgene.2022.1031806]. A study in humans identified the mir-1228 as significantly downregulated in plasma from patients with coronary artery disease compared to controls and validated this finding via qRT-PCR, where it demonstrated diagnostic utility with an AUC of 0.739 [Zhong et al. DOI:10.1002/jcla.23020]. Another study in humans found the mir-1228 was also among the top downregulated microRNAs in acute myocardial infarction patients, with qRT-PCR validation confirming its downregulation and showing a diagnostic AUC of 0.716 [Zhong et al. DOI:10.1002/jcla.23099].