Basic Information

Symbol
hsa-mir-421
RNA class
miRNA miRNA hairpin
Alias
MIR421 MicroRNA 421 Hsa-Mir-421 Hsa-MiR-421 MIRN421 Hsa-Mir-95-P2_pre MIMAT0003339 MI0003685
Location (GRCh38)
X:74218377-74218461
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-421
Sequence length
85 nt
GC content
0.3882

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.00 kcal/mol
Thermodynamic ensemble
Free energy: -36.12 kcal/mol
Frequency: 0.1629
Diversity: 3.97
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
.((((..((((((((((.{.((((((((((({,(((.........))))))))))))))).}.)))).))))))..)))).....
Forensic Context

A study in mice demonstrated that traumatic brain injury (TBI) at normal temperature induced significant up-regulation of the mir-421 by 2.89-fold at 4 hours post-injury, an effect that was also observed under low-temperature conditions with a 2.50-fold up-regulation [Wang et al. DOI:10.1258/ebm.2012.012123].