Basic Information
Symbol
hsa-miR-421
RNA class
miRNA
mature miRNA
Alias
hsa-miR-421
MIR421
MicroRNA 421
Location (GRCh38)
-
Forensic tag(s)
Sudden death from CNS diseases
Mechanical injury analysis
Wound age identification
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.00 kcal/mol
Thermodynamic ensemble
Free energy:
-36.12 kcal/mol
Frequency:
0.1629
Diversity:
3.97
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((..((((((((((...((((((((((((.(((.........)))))))))))))))...)))).))))))..)))).....
Thermodynamic Ensemble Prediction
.((((..((((((((((.{.((((((((((({,(((.........))))))))))))))).}.)))).))))))..)))).....
Forensic Context
A study in mice demonstrated that traumatic brain injury (TBI) at normal temperature induced significant up-regulation of the miR-421 by 2.89-fold at 4 hours post-injury, an effect that was also observed under low-temperature conditions with a 2.50-fold up-regulation [Wang et al. DOI:10.1258/ebm.2012.012123].