Basic Information

Symbol
hsa-mir-422a
RNA class
miRNA miRNA hairpin
Alias
MIR422A MicroRNA 422a Hsa-Mir-422a Hsa-MiR-422a MIRN422A MIMAT0001339 MI0001444 MiR-422a
Location (GRCh38)
15:63870930-63871019
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Individual identification Mechanical injury analysis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-422a
Sequence length
90 nt
GC content
0.5778

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-38.70 kcal/mol
Thermodynamic ensemble
Free energy: -39.53 kcal/mol
Frequency: 0.2611
Diversity: 7.92
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((.(((((..(((.(((((((.((((.(((((..(((((......).))))))))).)))).)))))))))).)))))...))).....
Forensic Context

A review of human studies identified the mir-422a as being downregulated in burn hypertrophic scar and its derived fibroblasts compared to normal fibroblasts [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the mir-422a was identified as a differentially expressed microRNA shared across two pairs of monozygotic twins, suggesting its potential role in distinguishing genetically identical individuals [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003]. Furthermore, research in human thermal-induced skin injury identified the mir-422a as one of many dysregulated miRNAs associated with hypertrophic scar formation [Wang et al. DOI:10.1007/s00438-024-02183-w].