Basic Information
Symbol
hsa-miR-422a
RNA class
miRNA
mature miRNA
Alias
hsa-miR-422a
MIR422A
MicroRNA 422a
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-38.70 kcal/mol
Thermodynamic ensemble
Free energy:
-39.53 kcal/mol
Frequency:
0.2611
Diversity:
7.92
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context
A review of human studies identified the miR-422a as being downregulated in burn hypertrophic scar and its derived fibroblasts compared to normal fibroblasts [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the miR-422a was identified as a differentially expressed microRNA shared across two pairs of monozygotic twins, suggesting its potential role in distinguishing genetically identical individuals [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003]. Furthermore, research in human thermal-induced skin injury identified the miR-422a as one of many dysregulated miRNAs associated with hypertrophic scar formation [Wang et al. DOI:10.1007/s00438-024-02183-w].