Forensic Context

A study in humans established a multi-class support vector machine classification model for forensic body fluid identification using TaqMan RT-qPCR, where the miR-423-3p was evaluated as a candidate reference gene for data normalization but demonstrated the lowest mean expression level among six candidates under the experimental conditions [Li et al. DOI:10.1016/j.fsigen.2024.103180]. A study in Sprague-Dawley rats demonstrated that the miR-423-3p was upregulated in lung tissue at 24 hours after burn injury, with a fold change of 2.94, and its differential expression was part of a profile linked to inflammation and apoptosis pathways [Zhang et al. DOI:10.5505/tjtes.2018.98123]. In traumatic brain injury research, the miR-423-3p is identified as a prognostic biomarker in human plasma, where it is elevated in the acute phase, predictive of severe TBI, and correlated with mortality and a higher risk of amnesia in mild TBI [Li et al. DOI:10.1016/j.neuint.2023.105643].