Forensic Context

A study in humans demonstrated that miR-423-5p was significantly elevated in plasma-derived exosomes from acute myocardial infarction patients compared to controls, identifying it as a potential postmortem diagnostic biomarker [Kim et al. DOI:10.3390/ijms25179619]. Research in mice showed that cocaine exposure decreased miR-423-5p's expression in aortic smooth muscle cells, leading to increased intracellular calcium and contractility, while its overexpression ameliorated cocaine-induced increases in blood pressure and aortic stiffness [Dykxhoorn et al. DOI:10.3390/Ijms24076584]. Smooth muscle-specific overexpression of the miR-423-5p in vivo effectively reversed these cocaine-induced cardiovascular pathologies.