Basic Information

Symbol
hsa-mir-424
RNA class
miRNA miRNA hairpin
Alias
MIR424 MicroRNA 424 Hsa-MiR-424-3p Hsa-MiR-424-5p Hsa-Mir-424 MIRN424 Hsa-Mir-15-P1c_pre MIMAT0001341 MIMAT0004749 MI0001446 MiRNA424 Mir-424 MIR322
Location (GRCh38)
X:134546614-134546711
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-424
Sequence length
98 nt
GC content
0.5102

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.80 kcal/mol
Thermodynamic ensemble
Free energy: -42.43 kcal/mol
Frequency: 0.3607
Diversity: 1.99
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((.((.((((((..(((((((((((((.((((...)))).)))))))))))))..)))))).)).))))))).....................
Thermodynamic Ensemble Prediction
(((((((.((.((((((..(((((((((((((.((({...}))).)))))))))))))..)))))).)).))))))).....................
Forensic Context

A study in humans demonstrated that hsa-miR-424-5p is downregulated in peripheral blood mononuclear cells from patients with sacubitril/valsartan resistance compared to non-resistant patients after acute myocardial infarction [Su et al. DOI:10.1016/j.ejphar.2023.175547]. A separate review of human skin studies reported that the mir-424 is upregulated in hypertrophic scar tissue compared to normal skin and is also upregulated in venous ulcers versus normal skin and acute wounds [Siu et al. DOI:10.1111/wrr.13100]. A review of the literature identifies the mir-424 as a hypoxamiR that is upregulated in response to hypoxia and functions to stabilize HIF-1α, positioning it as a diagnostic biomarker for asphyxia deaths [Scopetti et al. DOI:10.7150/ijms.79539].