Basic Information

Symbol
hsa-mir-425
RNA class
miRNA miRNA hairpin
Alias
MIR425 MicroRNA 425 Hsa-MiR-425-3p Hsa-MiR-425-5p Hsa-Mir-425 MIRN425 Hsa-Mir-425_pre MIMAT0001343 MIMAT0003393 MI0001448 Mir-425
Location (GRCh38)
3:49020148-49020234
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden death from CNS diseases Other applications
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-425
Sequence length
87 nt
GC content
0.5747

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.50 kcal/mol
Thermodynamic ensemble
Free energy: -36.13 kcal/mol
Frequency: 0.0706
Diversity: 12.84
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((((.((.{(((...(((((((.((.(((((.,{.{({{.,..,,.....}))),))))).)))))))))...)))).)).)))))
Forensic Context

A study in humans demonstrated that the mir-425 was upregulated in whole blood of patients with recurrent myocardial infarction after percutaneous coronary intervention, showing significant differential expression with a false discovery rate correction [Onuoha et al. DOI:10.1111/cts.13307]. In a separate human study investigating traumatic brain injury, microarray analysis indicated upregulation of the mir-425 in plasma from patients with mild TBI, though this finding was noted to differ from another study reporting downregulation [Qin et al. DOI:10.1371/journal.pone.0204051]. A study in mice demonstrated that the mir-425 was downregulated in corporal tissue in a model of diet-induced erectile dysfunction, with quantitative PCR validation confirming its significant downregulation [Barbery et al. DOI:10.1111/jsm.12793].