Basic Information

Symbol
hsa-miR-4286
RNA class
miRNA mature miRNA
Alias
hsa-miR-4286 MIR4286 MicroRNA 4286
Location (GRCh38)
-
Forensic tag(s)
Tissue/body fluid identification
External database
miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-miR-4286
Sequence length
17 nt
GC content
0.6471

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-27.10 kcal/mol
Thermodynamic ensemble
Free energy: -28.75 kcal/mol
Frequency: 0.3549
Diversity: 3.02
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((.(.((((.(((((.((((((((((((..(((...........)))..)))))).)))))).)).....))).)))).).))).....
Thermodynamic Ensemble Prediction
...{((.(.((((.(((((.((((((((((((..((({{{....}}}.)))..)))))).)))))).)}....,))).)))).).))}.....
Forensic Context

A study in humans established a multi-class support vector machine (MSVM) classification model for forensic body fluid identification using 14 microRNAs, where the miR-4286 was evaluated as a body fluid-specific marker for vaginal secretion (VS) identification [Li et al. DOI:10.1016/j.fsigen.2024.103180]. A review notes that miRNAs, including the miR-4286, show strongly increased expression in menstrual secretion and are used for identification via mathematical models like discriminant analysis [Courts et al. DOI:10.3238/arztebl.m2024.0051]. A study in humans demonstrated that the miR-4286 was identified as a candidate marker for vaginal secretion, appearing less specific than miR-193b-3p and miR-1260b but still contributing to body fluid differentiation within a set of 12 miRNAs that successfully distinguished five forensically relevant body fluids using RT-qPCR analysis [Altmeyer et al. DOI:10.1002/elps.202400089].