Basic Information

Symbol
hsa-mir-1231
RNA class
miRNA miRNA hairpin
Alias
MIR1231 MicroRNA 1231 Hsa-Mir-1231 Hsa-MiR-1231 MIRN1231 MIMAT0005586 MI0006321
Location (GRCh38)
15:64762387-64762515
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-1231
Sequence length
92 nt
GC content
0.5870

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-32.90 kcal/mol
Thermodynamic ensemble
Free energy: -33.54 kcal/mol
Frequency: 0.3564
Diversity: 13.37
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific dysregulation patterns observed in human skin tissue and cell lines post-thermal injury [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-1231 regulates Cacna2d2 in myocardial infarction and arrhythmias, where its overexpression in hearts after MI was associated with arrhythmic events and its suppression abrogated arrhythmias [Dykxhoorn et al. DOI:10.3390/Ijms24076584].