Basic Information
Symbol
hsa-miR-4325
RNA class
miRNA
mature miRNA
Alias
hsa-miR-4325
MIR4325
MicroRNA 4325
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-27.50 kcal/mol
Thermodynamic ensemble
Free energy:
-29.72 kcal/mol
Frequency:
0.7807
Diversity:
0.71
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
..,.{,....,,.|.|,,{((((({.(.((..(((((((..((((..((((....))))..))))..,,)}})))))..))).))))))}
Forensic Context
A study in humans demonstrated that the miR-4325 was differentially expressed and shared across five pairs of monozygotic twins, with its expression pattern validated by qRT-PCR [Xiao et al. DOI:10.1016/j.fsigen.2019.05.003]. The experimental findings, using miRNA microarray and qRT-PCR, showed differential expression in 9 of 18 twin pairs with a 2-fold change criterion and 11 pairs with a 1.5-fold change criterion, indicating its potential role as a biomarker for distinguishing genetically identical individuals in forensic identification.