Basic Information
Symbol
hsa-miR-1231
RNA class
miRNA
mature miRNA
Alias
hsa-miR-1231
MIR1231
MicroRNA 1231
Location (GRCh38)
-
Forensic tag(s)
Wound age identification
Sudden cardiac death diagnosis
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-32.90 kcal/mol
Thermodynamic ensemble
Free energy:
-33.54 kcal/mol
Frequency:
0.3564
Diversity:
13.37
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........((((((((((((..(((((..((((........(((..((((......))))..))).))))..)))))))))))..))).)))
Thermodynamic Ensemble Prediction
........((((((((((((..(((((..((((........(((..((((......))))..))).))))..)))))))))))..))).)))
Forensic Context
A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific dysregulation patterns observed in human skin tissue and cell lines post-thermal injury [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the miR-1231 regulates Cacna2d2 in myocardial infarction and arrhythmias, where its overexpression in hearts after MI was associated with arrhythmic events and its suppression abrogated arrhythmias [Dykxhoorn et al. DOI:10.3390/Ijms24076584].